Loading...

Description

Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living mammals. Because the microbiome is a major factor in mammalian physiology, we aimed to identify a naturally evolved reference microbiome to better recapitulate physiological phenomena relevant in the natural world outside the laboratory. Among 21 distinct mouse populations worldwide, we identified a closely related wild relative to standard laboratory mouse strains. Its bacterial gut microbiome differed significantly from its laboratory mouse counterpart and was transferred to and maintained in laboratory mice over several generations. Laboratory mice reconstituted with natural microbiota exhibited reduced inflammation and increased survival following influenza virus infection and improved resistance against mutagen/inflammation-induced colorectal tumorigenesis. By demonstrating the host fitness-promoting traits of natural microbiota, our findings should enable the discovery of protective mechanisms relevant in the natural world and improve the modeling of complex diseases of free-living mammals.

Summary

Project accession BioProject accession Keywords PMID #Samples
SRP109346 PRJNA390686 Ileocecum Mus musculus domesticus Wild mouse Wild 29056339 98

Alpha diversity

Samples

Sample accession Project accession Sampling location Genotype Vendor Origin
SRS2290241 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290244 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290243 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290240 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290239 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290242 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290237 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290238 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290234 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290233 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290217 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290216 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290214 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290215 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290213 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290212 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290211 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290210 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290209 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290208 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290206 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290207 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290205 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290201 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290203 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290204 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290202 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290200 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290198 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290175 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290167 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290165 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290163 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290164 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290162 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290161 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290160 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290159 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290157 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290158 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290148 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290140 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290136 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290134 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290124 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290121 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290117 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290119 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290107 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290106 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290104 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290103 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290102 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290105 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290099 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290100 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290101 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290096 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290093 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290086 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290085 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290084 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290082 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290081 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290079 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290076 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290078 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290075 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290077 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290073 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290072 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290074 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290061 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290059 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290083 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290055 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290058 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290056 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290057 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290051 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290053 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290052 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290049 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290048 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290050 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290039 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290032 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290031 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290023 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290021 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290024 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290020 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290018 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290019 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290014 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290017 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290016 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild
SRS2290015 SRP109346 Ileocecum Mus musculus domesticus Wild mouse Wild